![]() Only a minority presented with marked hyperkalaemia or other nonhormonal abnormalities. Half of the patients had elevated TSH levels. The most consistent biochemical finding of untreated AAD was low sodium independent of the degree of glucocorticoid deficiency. Serum cortisol was consistently decreased (median 62 nmol L −1 ) and significantly lower in individuals with adrenal crisis (38 nmol L −1 ) than in those without (81 nmol L −1, P < 0.001). Thirty-three per cent were diagnosed subsequent to adrenal crisis, in whom electrolyte disturbances were significantly more pronounced ( P < 0.001). TSH was elevated in 79 of 153 patients, and hypoglycaemia was found in 10%. Other common nonendocrine tests were largely normal. Low sodium occurred in 207 of 247 (84%), but only one-third had elevated potassium. Scrutiny of medical records provided patient data and laboratory values. Material and MethodsĪ multicentre retrospective study including 272 patients diagnosed with AAD at hospitals in Norway and Sweden during 1978–2016. Perform a retrospective audit of patient records with the aim of identifying biochemical markers for early diagnosis of AAD. The classical clinical picture of untreated AAD is well-described, but methodical investigations are scarce. ![]() ![]() Early detection of autoimmune Addison's disease (AAD) is important as delay in diagnosis may result in a life-threatening adrenal crisis and death.
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